Meghan Markle is making a surprise appearance in support of a good cause.

The Duchess of Sussex, 43, was an unexpected, but incredibly glamorous guest at the Children’s Hospital Los Angeles 2024 Gala on Saturday, Oct. 5.

Meghan paid a surprise visit to the event, which takes place every two years and pays tribute to CHLA’s patients and hospital pediatric workers, which include some of California’s best physicians, researchers and caregivers, according to the organization’s website. 

The Duchess looked stunning in a red Carolina Herrera gown (which she previously wore to the Salute to Freedom gala in New York in 2021) as she walked the red carpet holding hands with Alliance of Moms founder Kelly McKee Zajfen, as her husband Prince Harry, 40 — who has been in the African Kingdom of Lesotho this week — was not present at the event.

In an interview at the event posted on social media, Meghan praised the Children’s Hospital L.A. — where she led a Literally Healing session in March, reading favorite books of young patients to them — describing it as the “best place in the world” for children to receive treatment.

“Oh my goodness, the work they do at Children’s Hospital L.A. is otherworldy, and I think from my standpoint as a mother, no one wants to be in a position where you need to go to a place like this, but if you have to, the best place in the world you could go would be Children’s Hospital L.A.,” she said.

She went on to share that close friends of hers, including friends from high school, have children currently undergoing treatment at the hospital.

“The staff is incredible, and the amount of work they do for families that really could not afford this level of care is something that I think should never be overlooked,” the Duchess of Sussex continued.

“So I’m just grateful for everything they do,” she said, adding that she was, “happy to be here to support.”

During the evening Meghan took photos with a family whose kids are patients at the hospital and was spotted crouching down to take photos with the children as she talked to them. She also took a moment to chat with their father.

Inside the rooftop event, Meghan was all smiles as she greeted and spoke to a group of nurses from the hospital, taking time to speak with them all, as well as taking selfies with them. The Duchess was later escorted out of the event by a side door by a staff member, though she chatted to anyone who stopped her on her way out.

The hospital gala was hosted by Jon Cryer and Lisa Joyner and honored television producer and writer Chuck Lorre, former boxing champion and Sugar Ray Leonard and his wife Bernadette and Aeg.  

Other guests included Jamie Lee Curtis, Kaley Cuoco, Colin Hanks, Jimmy Kimmel and Molly McNearney, Sky and Mark Hoppus, Al Yankovic and Demi Lovato, who performed at the event. 

Meghan’s surprise appearance at the event comes as her husband Prince Harry was seen visiting Lesotho on Oct. 1 on a public engagement with his charity, Sentebale to discuss the HIV/AIDS crisis in southern Africa.

The Duchess, meanwhile, stayed at home in Montecito, Calif., as she continued to prepare for the launch of her upcoming  Netflix show and lifestyle brand, American Riviera Orchard, while looking after the couple’s two children, Prince Archie, 5, and Princess Lilibet, 3.

A close source previously told PEOPLE that Meghan and Harry, 40, are going through a shift in their ventures.

“It’s clear that a twin-track approach is evolving,” a friend told PEOPLE.

Another royal insider said, “The Duke and Duchess have now hit their stride as individuals – not just as a couple. The Duke appears focused on his patronage work, and the Duchess focused on her entrepreneurial track.”